Montepulciano stands on a high hill between the valleys of the Orcia and the Chiana Rivers (18 km from Montisi) and surrounded by a landscape that is sweeter than the countryside of the Orcia River and the crete.

This area is neatly farmed and possesses many monumental jewels that were erected, especially in the XVI century, with the contribution of architects such as Antonio da Sangallo, Baldassare Peruzzi and Jacopo Barozzi da Vignola. Of special note, amongst the many things, is the Church of San Biagio that stands alone below the hamlet and represents an exceptional example of sixteenth century Tuscan architecture. Montepulciano is also famous for its Vino Nobile (Noble Wine).

From Montepulciano, passing through Chianciano Terme, after 22 km you come to Chiusi that has very ancient origins. The city reached it maximum splendour from the VII to the V centuries BC, especially under the legendary King Porsenna. It is interesting to visit for its museum, which is full of Etruscan relics.

Also worth seeing is nearby Cetona, a town of Etruscan origin on the extremities of the mountain of the same name with its museum of prehistoric relics.